Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1669 | Thyroid (non-cancer) | ICEECE2012

The impact of TSH on diffusion of thyroglobulin through follicular lumina: possible relation to hormone formation

Milicevic Z. , Bajic V. , Kasapovic J. , Ciric J.

Although the physico-chemical properties of colloid are not usually considered among the factors regulating thyroid function, it is conceivable that decreasing the viscosity of the intrafollicular colloid may facilitate diffusion of thyroglobulin (Tg) molecules within the lumina. The resulting increase in the number of contacts between Tg molecules and peroxidase at the apical membrane may promote the coupling reaction. Rats on a hormonal diet were given 0.5 μg T4</s...